Scientists Succeed In Removing HIV From Living Tissue For The First Time

Way exciting development in the world of HIV research.

From the Independent:

Scientists have managed to remove DNA of the HIV virus from living tissue for the first time in a breakthrough that could lead to an outright cure. At the moment, treating the disease involves the use of drugs that suppress levels of the virus so the body’s immune system can cope.

Now researchers in the US have revealed they used gene-editing technology to remove DNA of the commonest HIV-1 strain from several organs of infected mice and rats.

In April, the same team reported that they had successfully eliminated the virus from human cells in the laboratory, but a paper in the journal Nature Gene Editing revealed they had managed to do the same thing in live animals for the first time.

The researchers’ team leader, Professor Kamel Khalili, of Temple University, said: “In a proof-of-concept study, we show[ed] that our gene-editing technology can be effectively delivered to many organs of two small animal models and excise large fragments of viral DNA from the host cell genome.”

News Round-Up: May 18, 2016

Frankie J. Alvarez, Jonathan Groff and Murray Bartlett of LOOKING

Some news stories you may have missed:

• HBO will premiere the “wrap-up movie” of it’s now-cancelled gay series Looking July 23rd at 10PM.  I was a big fan of the series, so I’ll definitely be watching 🙂

• 72% of New Jersey Gov. Chris Christie’s own constituents don’t want to see him be Trump’s veep pick. With friends like these…

• RuPaul tells ABC News that he doesn’t think RuPaul’s Drag Race could ever go “mainstream.”

•Donald Trump says he would “protect all people” in the same breath he mentions he would rescind President Obama’s historic directives protecting transgender folks from discrimination. But he loves everyone, don’t you know…

• Frequent homophobe Azealia Banks got her butt booted from Twitter for her homophobic/racist rant on former One Direction member Zayn Malik.

• In addition to a win for Hillary Clinton, last night’s Kentucky primary also produced the state’s first openly gay Democratic Senate candidate.

• Ted Olson, who successfully argued for the demise of California’s Prop 8, has been brought on to author an amicus brief in support of the Department of Justice’s lawsuit challenging North Carolina’s hateful HB2 law.

• Hillary Clinton calls for the decriminalization of HIV. Just one more reason why #ImWithHer

Hillary Clinton Meets With HIV/AIDS Experts & Advocates

Longtime AIDS activist Peter Staley  with Hillary Clinton

Although Sen. Bernie Sanders cancelled his scheduled meeting with HIV/AIDS experts and activists, former Secretary of State Hillary Clinton today met with a diverse coalition of more than 70 leaders and organizations in the HIV community.

Longtime HIV/AIDS activist Peter Staley just posted this after taking part in the meeting:

We started about an hour late, but she stayed well beyond our budgeted 45 minutes — over an hour, in the end. A frank exchange. It was a first step in what we all agreed would be an ongoing process with her campaign. No surprise — she’s an HIV wonk.

Among other things, Hillary proposed expanding access to PrEP for prevention,  protect HIV+ folks from discrimination, and increase HIV/AIDS research.

Via press release:

The meeting took place at the Hillary for America headquarters in Brooklyn, NY, where they discussed Clinton’s continued commitment to tackling the epidemic in the U.S. and globally, fighting discrimination against PLHIV and AIDS, and working together with HIV and AIDS experts and advocates to achieve an AIDS-free generation.

Hillary Clinton has been a longtime advocate in the fight to treat and prevent HIV and AIDS.

As First Lady, Clinton traveled the world to raise awareness on combating HIV and AIDS and assembled government officials and world leaders to increase funding for prevention and research efforts.

As Senator, Clinton introduced legislation to improve and expand global HIV and AIDS research, assistance, and education. She also co-sponsored the Early Treatment for HIV Act to extend Medicaid coverage to low-income people living with HIV.

As Secretary of State, Clinton began an ambitious campaign to usher in an AIDS-free generation. She oversaw a more than 200 percent increase in the number of people on antiretroviral treatment directly supported by the United States to reach over 6.7 million men, women, and children around the world.

Clinton has also emphasized HIV and AIDS in her philanthropic work. Almost 10 million people with HIV or AIDS around the world have benefited from more affordable medicine because of the Clinton Foundation. And since 2002, the Clinton Health Access Initiative has reduced the cost of HIV and AIDS medications in many countries from over $10,000 per person per year to just $100 to $200 per person per year.

During this campaign, Clinton has released specific policies to tackle the HIV and AIDS epidemic. As President, she will:

Cap out-of-pocket pharmaceutical expenses for people with HIV and AIDS. Clinton has announced a plan to hold the pharmaceutical industry accountable and to achieve lower drug costs for Americans, including for medications that help treat HIV and reduce the risk of contracting AIDS. Clinton will ensure that Americans can get the care their doctors prescribe by requiring health insurance plans to cap covered out-of-pocket prescription drug costs at $250 per month. She also will allow Medicare to negotiate lower drug prices and will stop direct-to-consumer advertising subsidies for drug companies—reinvesting those funds in research.

Expand the utilization of HIV prevention medications, including pre-exposure prophylaxis (PrEP). While we work to diagnose and treat all Americans with HIV and AIDS, we also must work to prevent exposure. Decades of research are beginning to offer a promising path to prevention. Clinton will increase the CDC investment to ensure populations at greatest risk of infection have access to PrEP, and encourage states to follow suit.

Protect those with HIV and AIDS from discrimination. Clinton will work with Congress to review and reform outdated and stigmatizing HIV criminalization laws—and call on states to do the same. And she is committed to continuing to aggressively enforce the Americans with Disabilities Act and other civil rights laws to fight HIV-related discrimination.

Continue to increase HIV and AIDS research and invest in the promising innovations that research is producing. Researchers at the NIH and elsewhere are poised to make even more progress towards curing HIV, developing long-acting treatments that do not require daily pill taking, and better understanding the social and structural factors that can impact a person’s ability to access HIV prevention and care services. As President, Clinton will increase funding to ensure this progress to continue.

Bernie Sanders Cancels Meeting With HIV Activists With No Explanation Or Reschedule

Sen. Bernie Sanders

Chris Johnson of the Washington Blade is reporting that Sen. Bernie Sanders cancelled a scheduled meeting with HIV activists that was promised by his campaign just days before the New York Democratic primary.

The 30-minute meeting between Sanders and HIV advocates was set for May 3 in Indianapolis.

Democratic front-runner Hillary Clinton had also agreed to meet the activists, who say they’re are still on track to meet with her Thursday for one hour in New York City.

Hilary McQuie, director of U.S. policy and grassroots mobilization for the HIV/AIDS group Health GAP, told the Blade the Sanders campaign had cancelled the meeting without explanation.

“He did cancel — no reason given and they have not rescheduled,” McQuie said. “We feel a bit burned by the bern, and hope they will answer our emails now.”

Peter Staley, a New York-based gay rights and HIV advocate, told the Blade HIV advocates before the unexpected cancellation were in daily contact with the Sanders campaign.

“They sent a ‘need to reschedule’ email last Sunday (for our Tuesday meeting), and then bizarrely stopped communications completely after that,” Staley said. “We’ve been emailing and calling every day since then, including warning them days ago about our intent to go public.”

According to a statement announcing the cancellation from the Brooklyn-based HIV and homeless advocacy group Housing Works, attendees were informed on April 30 the Sanders meeting was cancelled, which was two days after many of them purchased expensive, last-minute plane ticket to attend the event.

Although the Sanders campaign promised to “reschedule” as soon as possible, it has yet to propose a new date, time or city, the statement says.

The Sanders campaign didn’t respond to a request to comment late Sunday to confirm the meeting with HIV advocates was cancelled or to explain why the event would be nixed.

Hmm. You could almost get the sense that the Sanders campaign “played” the activists to appear more concerned about HIV than Sanders really is to get the support of the LGBT community which is strong in New York state.

I don’t know if that’s true, but seems like one of those things that make you go “hmmm….”

Watch this report from MSNBC:

Hillary Clinton Circles Back To Reagan/AIDS Comment With Depth

Former Secretary of State Hillary Clinton has issued a second and far more in-depth response to her misstatements about the Reagans’ record on AIDS/HIV.

As someone who felt great hurt by her overreach about the role of the Reagans in terms of AIDS in the 1980s, I feel this is thoughtful and heartfelt.

I appreciate that she came back to this with more than a simple apology.

Clinton’s full statement:

Yesterday, at Nancy Reagan’s funeral, I said something inaccurate when speaking about the Reagans’ record on HIV and AIDS. Since then, I’ve heard from countless people who were devastated by the loss of friends and loved ones, and hurt and disappointed by what I said. As someone who has also lost friends and loved ones to AIDS, I understand why. I made a mistake, plain and simple.

I want to use this opportunity to talk not only about where we’ve come from, but where we must go in the fight against HIV and AIDS.

To be clear, the Reagans did not start a national conversation about HIV and AIDS. That distinction belongs to generations of brave lesbian, gay, bisexual, and transgender people, along with straight allies, who started not just a conversation but a movement that continues to this day.

The AIDS crisis in America began as a quiet, deadly epidemic. Because of discrimination and disregard, it remained that way for far too long. When many in positions of power turned a blind eye, it was groups like ACT UP, Gay Men’s Health Crisis and others that came forward to shatter the silence — because as they reminded us again and again, Silence = Death.

They organized and marched, held die-ins on the steps of city halls and vigils in the streets. They fought alongside a few courageous voices in Washington, like U.S. Representative Henry Waxman, who spoke out from the floor of Congress. Then there were all the people whose names we don’t often hear today — the unsung heroes who fought on the front lines of the crisis, from hospital wards and bedsides, some with their last breath.

Slowly, too slowly, ignorance was crowded out by information. People who had once closed their eyes opened their hearts. If not for those advocates, activists, and ordinary, heroic people, we would not be where we are in preventing and treating HIV and AIDS. Their courage — and their refusal to accept silence as the status quo — saved lives.

We’ve come a long way. But we still have work to do to eradicate this disease for good and to erase the stigma that is an echo of a shameful and painful period in our country’s history. This issue matters to me deeply. And I’ve always tried to do my part in the fight against this disease, and the stigma and pain that accompanies it. At the 1992 Democratic National Convention, when my husband accepted the nomination for president, we marked a break with the past by having two HIV-positive speakers — the first time that ever happened at a national convention.

As First Lady, I brought together world leaders to strategize and coordinate efforts to take on HIV and AIDS around the world. In the Senate, I put forward legislation to expand global AIDS research and assistance and to increase prevention and education, and I proudly voted for the creation of PEPFAR and to defend and protect the Ryan White Act. And as secretary of state, I launched a campaign to usher in an AIDS-free generation through prevention and treatment, targeting the populations at greatest risk of contracting HIV.

The AIDS crisis looks very different today. There are more options for treatment and prevention than ever before. More people with HIV are leading full and happy lives. But HIV and AIDS are still with us. They continue to disproportionately impact communities of color, transgender people, young people and gay and bisexual men. There are still 1.2 million people living with HIV in the United States today, with about 50,000 people newly diagnosed each year. In Sub-Saharan Africa, almost 60 percent of people with HIV are women and girls. Even though the tools exist to end this epidemic once and for all, there are still far too many people dying today.

That is absolutely inexcusable.

I believe there’s even more we can — and must — do together. For starters, let’s continue to increase HIV and AIDS research and invest in the promising innovations that research is producing. Medications like PrEP are proving effective in preventing HIV infection; we should expand access to that drug for everyone, including at-risk populations. We should call on Republican governors to put people’s health and well-being ahead of politics and extend Medicaid, which would provide health care to those with HIV and AIDS.

We should call on states to reform outdated and stigmatizing HIV criminalization laws. We should increase global funding for HIV and AIDS prevention and treatment. And we should cap out-of-pocket expenses and drug costs—and hold companies like Turing and Valeant accountable when they attempt to gouge patients by jacking up the price of lifesaving medications.

We’re still surrounded by memories of loved ones lost and lives cut short. But we’re also surrounded by survivors who are fighting harder than ever.

We owe it to them and to future generations to continue that fight together. For the first time, an AIDS-free generation is in sight. As president, I promise you that I will not let up until we reach that goal. We will not leave anyone behind.

Documentary: “Last Men Standing”

A new documentary produced by the San Francisco ChronicleLast Men Standing – examines the lives of men diagnosed in the early years of the AIDS epidemic who have survived to tell their stories.

These are stories of survival and loss; courage and fear; histories and horizons. Through the course of the film, eight men explore and explain the lives they’ve lived that they never expected to have.

One of the men featured in the film, Peter Greene, says “I’m the luckiest unlucky person in the world. No one wants to be the last man standing.”

The documentary will be screened at the Castro Theater in San Francisco on April 8. Click here for ticket info.

New Approach In HIV Treatment Shows Big Success In Phase One Trials

Newly completed Phase 1 clinical trials of a new HIV treatment look promising and could lead the way to a new approach to stopping HIV using antibodies.

From the San Diego Tribune:

The drug is an antibody that neutralizes a broad range of HIV strains. The broadly neutralizing antibody, called VRC01, reduced the level of circulating virus more than 10-fold in 6 of 8 HIV-positive patients who had not received antiviral drugs.

The other two were found to have a strain of HIV resistant to the antibody. And in 15 people whose infection was already suppressed with antiviral therapy, the antibody had no effect.

In all 23 patients tested, the antibody was found safe. VRC01 kills about 90 percent of HIV strains.

Because the antibodies are made by the body, after being “trained” by the vaccine, this approach is called active immunization. Administering a prepared broadly neutralizing antibody is known as passive immunization, because it doesn’t rely on an immune response from the patient. The antibody directly attacks the virus.

While active immunization is generally the best way to fight disease, an effective HIV vaccine hasn’t been yet developed. So developing more and better treatments to stop HIV remains a high priority.

World AIDS Day: “When Dogs Heal”

Dr. Robert Garofalo and Fred

When Dogs Heal is a photographic project that tells the stories of people who believe that the best medicine may not always be found at a pharmacy or in a doctor’s office; sometimes it comes in the form of a four-legged friend.

The project began with Dr. Robert Garofalo and his dog, Fred, who he adopted shortly after surviving cancer and later being diagnosed with HIV. Dr. Garofalo credits Fred for getting him through some of his darkest moments and helping him rediscover peace and joy in his life — things he thought he may have lost forever.

Information about project gallery exhibits and more at the official website.

(h/t JMG)

Dr. Frank Spinelli: The Stigma/Fears Faced During Height Of HIV/AIDS Epidemic

As part of observance of World AIDS Day today, Dr. Frank Spinelli, HIV/AIDS specialist, reminds us of the stigma and fears many gay men felt in the 1980s/90s during the early years of the epidemic.

This mindset still continues today even though there are anti-retroviral drugs which can make an HIV+ diagnosis manageable for many. That stigma keeps a lot of folks from getting tested, which is the important first step to getting the syndrome under control.

(h/t Queerty)